Zinc Oxide (ZnO) is one of the most exploitable nanoparticles (NPs) in industrial and consumer products especially in cosmetics, food additives, pharmaceuticals, biosensors, photo electricity and rubber industry etc. eCollection 2020. After standard phases of preparation, injections were done intraperitoneally in chronic groups with zinc oxide nanoparticles (20 and 40 mg/kg) every other day and for acute groups with 200 and 400 mg/kg in a single dose.  |  Biosynthesis of zinc oxide nanoparticles using. Zinc oxide nanoparticles induced cyto- and genotoxicity in kidney epithelial cells. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. Please enable it to take advantage of the complete set of features! Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. Epub 2015 Nov 6. The ZnO nanomaterials release into the aquatic ecosystems through domestic and industrial wastewaters has the potential to induce pernicious effects on fish and other organisms. Zinc oxide (ZnO) has been characterized as a “Generally Recognized as Safe” (GRAS) compound by the US FDA and exhibits minimal toxicity to humans. There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. They can also be utilized as a self-cleaning coating material on glass and ceramic surfaces. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Zinc oxide (ZnO) has long been recognized as an effective sunscreen agent. The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata. COVID-19 is an emerging, rapidly evolving situation. Toxicity of zinc oxide nanoparticles through oral route Surekha Pasupuleti, Srinivas Alapati, Selvam Ganapathy, Goparaju Anumolu, Neelakanta Reddy Pully, and Balakrishna Murthy Prakhya Toxicology and Industrial Health 2011 28 : 8 , 675-686 Recently, various approaches including physical, chemical and biological ("green chemistry") have been used to prepare ZnO nanocomposites with different morphologies.  |  2014;6(24):15333–15342. Nano-Micro Letters, 7, 219-242 (2015). Effect of annealing temperature on antimicrobial and structural properties of bio-synthesized zinc oxide nanoparticles using flower extract of Anchusa italica. 45. NLM  |  This site needs JavaScript to work properly. Zinc oxide NPs can be synthesized by a number of physical, chemical and biological methods. Biosynthesis of zinc oxide nanoparticles by cell-biomass and supernatant of Lactobacillus plantarum TA4 and its antibacterial and biocompatibility properties. Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism View 0 peer reviews of Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism on Publons COVID-19 : add an open review or score for a COVID-19 paper now to ensure the latest research gets the extra scrutiny it needs. Clipboard, Search History, and several other advanced features are temporarily unavailable. The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. acute and chronic doses; blood parameters; liver tissue. Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. While their general toxicity and associated oxidative stress have been extensively studied, the toxicological pathways that they induce in developmental stages are still largely unknown. Front Chem. Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. After the determined time for every group (21 days for chronic groups and 7 days for acute groups), blood samples were provided from rat hearts and also liver, kidney and testicular tissue were removed for histological studies. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. The nanoparticles (NPs) have been increasingly manufactured in industry because of the well-known characteristics such as high reactivity, electromagnetic properties and high antibacterial property [].Zinc oxide nanoparticle (nZnO), one of the most popular manufactured metal oxide nanomaterials, has unique properties (i.e., surface area and reactive sites) due to the extremely small … 2016 Jan;100(2):571-81. doi: 10.1007/s00253-015-7108-x. Hidden toxicity of zinc oxide nanoparticles. Keywords: sativus) plants. However, under seasonal variation and global climate change, marine organisms are exposed to a changing environment with different regimes of temper Environmental Science: Nano Recent HOT Articles Yet despite the potentially interesting antitumor activity of ZnO nanoparticles, it has been proven that they can be also cytotoxic and genotoxic for multiple types of human cells (i.e. PMID: 30489211 [Indexed for MEDLINE] Publication Types: Review; MeSH terms. Epub 2015 May 18. USA.gov. Microb Pathog. Nowadays, a lot of studies were carried out about side effects of nanoparticles especially nano-zinc oxide, but unfortunately, most of these studies have been conducted with high doses. A combined toxicity study of zinc oxide nanoparticles and vitamin C in food additives. eCollection 2019. Accute Toxicity Satureja ZnO Nanoparticles Bioassay Test LC 50 96h Abstract Nanoparticles are commonly synthesized chemically and because of their risk for living was carried out to evaluate the acute toxicity of zinc oxide nanoparticles synthesized from Satureja hortensis on rainbow trout (Oncorhynchus mykiss) by static bioassay test. Khan MF, Husain FM, Zia Q, Ahmad E, Jamal A, Alaidarous M, Banawas S, Alam MM, Alshehri BA, Jameel M, Alam P, Ahamed MI, Ansari AH, Ahmad I. ACS Omega. This study investigates the toxic effects of ZnO-NPs in human lung cells. 2018 Apr 25;286:60-70. doi: 10.1016/j.cbi.2018.03.008. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area … It indicates an important role of Zn 2 + ions in the cytotoxicity of zinc oxide nanoparticles. J Nanosci Nanotechnol 2010, 10: 8617–8624. Toxic effect of nano-zinc oxide There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. Amara S, Slama IB, Mrad I, Rihane N, Khemissi W, El Mir L, Rhouma KB, Abdelmelek H, Sakly M. Hum Exp Toxicol. Happy Agarwal, Soumya Menon, Venkat Kumar S, Rajeshkumar S. Chem Biol Interact. Fouda A, El-Din Hassan S, Salem SS, Shaheen TI. 2015;25(4):334-9. doi: 10.3109/15376516.2015.1045654. 2018 Apr;254:100. doi: 10.1016/j.cis.2018.04.006. Zinc oxide nanoparticles (ZnO-NPs) are among nanoscale materials displaying exponentially growing production due to their applications in the field of cosmetology, medicine, as antibacterial agent and catalyst. RESEARCH ARTICLE Zinc oxide and silver nanoparticles toxicity in the baker’s yeast, Saccharomyces cerevisiae Imelda Galva´ n Ma´ rquez1, Mergan Ghiyasvand1, Andrey Massarsky2¤, Mohan Babu3, Bahram Samanfar1,4, Katayoun Omidi1, Thomas W. Moon2, Myron L. Smith1*, Ashkan Golshani1* 1 Department of Biology and Ottawa Institute of Systems Biology, Carleton University, … Azizi S, Mohamad R, Bahadoran A, Bayat S, Rahim RA, Ariff A, Saad WZ. 2012 May 2;12:60. doi: 10.1186/1472-6882-12-60. NLM Uzar NK, Abudayyak M, Akcay N, Algun G, Özhan G. Toxicol Mech Methods. HHS Using ICP-MS and fluorescent-labeled ZnO, it is found that ZnO dissolution could happen in culture medium and endosomes. Clipboard, Search History, and several other advanced features are temporarily unavailable. It is now widely recognized that dissolution plays an important role in metallic nanoparticle toxicity, but to what extent remains unclear. In this study, we investigated the effect of various concentrations of zinc oxide (ZnO) NPs (0, 1, 5, 20, 100, and 1000 mg kg −1 of soil) on lettuce (Lactuca sativa L.) and carrot (Daucus carota subsp. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Material and methods: neuronal or epithelial cells). Zinc is a Block D, Period 4 element, while Oxygen is a Block P, Period 2 element. 2016 Dec;35(12):1286-1304. doi: 10.1177/0960327116629530. Furthermore, zinc oxide nanoparticles induced cytotoxicity in human lung epithelial cells via inducing oxidative stress in a concentration-dependent manner, resulting in DNA damage and apoptosis [36 Sahu D, Kannan GM, Vijayaraghavan R, Anand T, Khanum F. Nanosized zinc oxide induces toxicity in human lung cells. In the present study 36 male Wistar rats with approximate age of two months and weighing 300±30 g were selected. A severe to slight damage was observed in liver tissue in all groups and tissue destruction was seen in kidney only in acute dose treated groups but no specific pathological effect in testis was observed (Fig.  |  Would you like email updates of new search results? Nanoscale. The current hazard assessment of the emerging chemical contaminant, zinc oxide nanoparticles (ZnO-NPs), seldom considers the influence of environmental factors.  |  Please enable it to take advantage of the complete set of features! A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats: Toxicity study of zinc oxide nanoparticles. ; nano-zinc oxide; oxidative stress. Corrigendum to "Zinc oxide nanoparticles: synthesis, antiseptic activity and toxicity mechanism" Adv Colloid Interface Sci 249 (2017) 37-52. Silver and zinc oxide nanoparticles (Ag and ZnO NPs) are widely used as antimicrobial agents. Would you like email updates of new search results? Keywords: Microbial Fabrication of Zinc Oxide Nanoparticles and Evaluation of Their Antimicrobial and Photocatalytic Properties. The study used nanoparticulate ZnO (ca. 30 nm) showed that small particles in aquatic systems and their bioavailability does not have to be significantly greater than that of larger particles. 43). It has been shown that maximum exposure concentration of zinc oxide (125 mg/l) suspension released 6.8 mg/l of Zn 2+ ions. 2018 Dec 20;14:87-100. doi: 10.2147/IJN.S186888. HHS Epub 2014 Feb 5. The increasing focus on nano zinc oxide resulted in the invention and development of methods of nanoparticles synthesis. Zinc oxide nanoparticles (ZnO NPs) are being utilized in an increasing number of fields and commercial applications. This site needs JavaScript to work properly. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. Literatures available on ZnO nanoparticles toxicity suggest that dissolution, organism dependent cellular uptake, generation of reactive oxygen species (ROS), and induced inflammatory responses seem to be common factors which govern the toxicity of ZnO nanoparticles. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Bobrowska-Korczak B, Gątarek P, Skrajnowska D, Bielecki W, Wyrebiak R, Kovalczuk T, Wrzesień R, Kałużna-Czaplińska J. Nutrients. Zitao Zhou, Jino Son, Bryan Harper, Zheng Zhou, Stacey Harper, Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish, Beilstein Journal of Nanotechnology, 10.3762/bjnano.6.160, 6, (1568-1579), (2015). 2020 Oct 2;15:7329-7358. doi: 10.2147/IJN.S265934. However, their potential toxicological impact on environmental microorganisms is largely unexplored. USA.gov. Zinc oxide nanoparticles (ZnO-NPs) have been reported as an antimicrobial agent against both pathogenic and spoilage microorganisms ... L. C., Bakhori, S. K. 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