In Becker muscular dystrophy, weakness may be limited to the quadriceps (muscles in the front of the thigh). Becker muscular dystrophy is caused when the body does not produce enough dystrophin (a vital muscle protein) or when the dystrophin does not work properly. A physical exam indicates lack of pectoral and upper arm muscles, especially when the disease is unnoticed through the early teen years. Carrier females have a 50% chance of passing the DMD mutation in each pregnancy. This would lead to easy fatigue with even minimal activity. Muscular dystrophy is caused by genetic mutations that interfere with the production of muscle proteins that are needed to build and maintain healthy muscles. Muscular dystrophy can be inheirited, or occur for the first time in an individual. Some symptoms consistent with Becker muscular dystrophy are: Individuals with this disorder typically experience progressive muscle weakness of the leg and pelvis muscles, which is associated with a loss of muscle mass (wasting). Onset at around age 7 to 8 years of age shows more cardiac involvement and trouble climbing stairs by age 20, if onset is around age 12, there is less cardiac involvement. In some cases, it may cause heart problems, which may increase the risk of stroke and sudden death, thereby reducing the lifespan. The causes are genetic. A minority of females with the mutation are manifesting carriers, who usually have a mild form of the disorder. The gene is located on the X chromosome. A 29-year-old male asked: difference between duchnne & becker muscular dystrophy. Treatment focuses on symptom management and can include steroids, physical therapy, breathing support devices and surgery. Becker's muscular dystrophy is a less severe form of the disease. BMD is inherited in an X-linked pattern. X-linked recessive inherited disorder characterized by slowly progressive muscle weakness of the legs and pelvis, Centers for Disease Control and Prevention, "Becker muscular dystrophy: MedlinePlus Medical Encyclopedia", "Becker's Muscular Dystrophy information. It is a neuromuscular disorder that occurs in three to six of every 100,000 births, and in people of all races. Becker muscular dystrophy can cause cardiomyopathy, a weakening of the heart muscles, which, if unaddressed, can lead to heart failure and the need for a transplant. For more information, see MDA’s booklet Facts About Genetics and Neuromuscular Diseases, and the 2012 video Genetics of BMD: Why Your Mutation Matters. Terms of Use | State Fundraising Notices. A man with BMD can’t pass the flawed gene to his sons because he gives a son a Y chromosome, not an X. This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention. There are two possible explanations: If a mother gives birth to a child with BMD, there’s always the possibility that more than one of her egg cells has a dystrophin gene mutation, putting her at higher-than-average risk for passing the mutation to another child. Calf muscles initially enlarge during the ages of 5-15 (an attempt by the body to compensate for loss of muscle strength), but the enlarged muscle tissue is eventually replaced by fat and connective tissue (pseudohypertrophy) as the legs become less used (with use of wheelchair). BMD is less severe than DMD. BMD can run in a family, even if only one person in the biological family has it. The genetic mutation leading to BMD may have existed in the females of a family for some generations without anyone knowing it. “Becker Muscular Dystrophy (for Parents).” Edited by Mena T. Scavina, This page was last edited on 24 November 2020, at 21:59. BMD carriers are at risk for cardiomyopathy (see Signs and Symptoms). [14][22], The quality of life for patients with Becker muscular dystrophy can be impacted by the symptoms of the disorder. Why don’t girls usually get BMD? The dystrophinopathies cover a spectrum of X-linked muscle disease ranging from mild to severe that includes Duchenne muscular dystrophy, Becker muscular dystrophy, and DMD-associated dilated cardiomyopathy (DCM). [23], Becker muscular dystrophy is named after the German doctor Peter Emil Becker who published an article about it in 1955.[24][25]. This is because of the different ways in which genetic diseases are inherited. Becker muscular dystrophy affects the muscles of the hips, pelvic area, thighs and shoulders, as well as the heart.Becker muscular dystrophy (BMD) is one of nine types of muscular dystrophy, a group of genetic, degenerative diseases primarily affecting voluntary muscles. 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