+44 (0)20 3660 8427E-mail: press@ema.europa.euFollow us on Twitter @EMA_News, European Medicines AgencyDomenico Scarlattilaan 61083 HS AmsterdamThe Netherlands. Prevention and long-term control are key in stopping asthma attacks before they start. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. Posted 10th May 2019 by Simon Albert. The CHMP’s opinion recommends to extend the indication to add-on maintenance treatment for adult and adolescent (12 years and older) severe asthma patients with type II inflammation characterised by increased blood eosinophils and/or raised exhaled nitric oxide measured by FeNO test and inadequately controlled by inhaled high dose corticosteroids plus another asthma medicinal product. Biologic therapies are a new type of medicine which works in a different way to traditional asthma treatments. and Terms of Use. New Zealand Search. The content is provided for information purposes only. Dr. Keenan said the team's research could dramatically improve the future of asthma treatment because they had identified a small molecule inhibitor, or drug, that could target the cause of disease, rather than just alleviating the symptoms. A combination of an inhaled short-acting anticholinergic and an inhaled short-acting beta agonists. New recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. Introducing fevipiprant to the asthma market will offer a new way to tackle airway smooth muscle buildup, one of the strongest predictors of airflow limitation. EMA Press officeTel. Once a marketing authorisation has been granted, decisions about price and reimbursement will take place at the level of each Member State, taking into account the potential role/use of this medicine in the context of the national health system of that country. You … Mepolizumab, reslizumab, and benralizumab treat severe asthma that’s caused by a type of white blood cell called an eosinophil (eosinophilic asthma). New add-on treatment for patients with severe asthma Press release 01/03/2019 EMA’s human medicines committee ( CHMP ) has recommended granting an extension of indication to Dupixent (dupilumab) as an add-on maintenance treatment for adult and adolescent (12 years and older) patients with certain forms of severe asthma. The benefits and safety of Dupixent have been studied in three pivotal trials including a total of 2,888 patients. “This new treatment, Fevipiprant, could likewise help to stop preventable asthma attacks, reduce hospital admissions and improve day-to-day symptoms- making it a ‘game changer’ for future treatment.” To test the efficacy of the three-in-one treatment, researchers sponsored by Italian drugmaker Chiesi Farmaceutici, recruited more than 2,500 asthma … That’s why we’ve highlighted advice for childhood asthma, including the kid’s first aid for asthma protocol, in the new Guide. This document is subject to copyright. "Our early research identified that the enzyme Ezh2, which is an essential component of the epigenome, was critical to the immune system's ability to drive inflammation in response to allergens. Doctors can create a plan or strategy which includes new asthma treatment. Dupixent is already approved in the European Union for adult patients with atopic dermatitis who are candidates for systemic therapy. They can improve symptoms and reduce asthma attacks in people with severe asthma … EMA is in the process of making appropriate changes to this website. This article, titled "A controlled trial of budesonide-formoterol as needed for mild asthma, found that use of this medication combination as needed was superior to albuterol for the prevention of asthma exacerbations, a primary goal of asthma care. Get weekly and/or daily updates delivered to your inbox. Click here to sign in with The most common side effects of Dupixent are infections, eye disorders (conjunctivitis and related conditions) and injection site reactions. The 2019 GINA strategy report represents the most important change in asthma management in 30 years. This indicated that an Ezh2 inhibitor drug could effectively suppress inflammation in an allergic response," he said. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. Neither your address nor the recipient's address will be used for any other purpose. Current treatments for asthma are Short-acting beta agonists – they work to rapidly reduce the symptoms within minutes, they are inhaled bronchodilators. This type of asthma is one of the most debilitating forms of the condition, involving an inflammation of the airways linked to a particular type of white blood cell (eosinophils). EMA’s human medicines committee (CHMP) has recommended granting an extension of indication to Dupixent (dupilumab) as an add-on maintenance treatment for adult and adolescent (12 years and older) patients with certain forms of severe asthma. In a study of over 200 participants with severe asthma, the new treatment was shown to have improved asthma … Thank you for taking your time to send in your valued opinion to Science X editors. Therapeutic options are limited for patients with severe asthma whose symptoms cannot be controlled with the available treatments such as high dose inhaled corticosteroids. The 2019 update includes a complete revision of the section on monitoring asthma including new information on predicting future risk of asthma attacks, and updates to the sections on pharmacological management of asthma, supported self management, non-pharmacological management of asthma, and management of acute asthma in adults and children. Due to safety concerns, GINA … Anti-inflammatory steroids are associated with many side-effects. 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